C7orf77

Across TCGA pan-cancer cohorts, C7orf77 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of C7orf77’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where C7orf77 RNA is repressed in tumor relative to normal tissue. In most cancer types C7orf77 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and BRCA are the cancer types where C7orf77 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C7orf77 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.309	<.001	7	view →
LUAD	All	All	−0.148	.002	5	view →
BRCA	All	All	+0.096	<.001	4	view →
LIHC	All	All	+0.331	.005	2	view →
KIRC	All	All	+0.033	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

C7orf77–LUSC

Open the LUSC breakdown →