Across TCGA pan-cancer cohorts, C7orf66 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of C7orf66’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where C7orf66 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C7orf66 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

UCEC and THCA are the cancer types where C7orf66 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C7orf66 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	+0.132	.026	2	view →
THCA	Female	All	−0.036	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: C7orf66 RNA expression & survival · all C7orf66 data types