C7

Across TCGA patient cohorts, C7 mutation is significantly associated with the RNA expression of many other genes, with 5,041 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C7-associated genes across cancer lineages are HELLS, E2F2, and WDR76. Each is linked with C7 in more than 4 cancer types. Because this analysis shows association rather than direction, both C7-to-partner and partner-to-C7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELLS grouped by C7-low versus C7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C7→partner) and Y-score (partner→C7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HELLS →	+0.360	+1.369	.008	.009	3	5
LUAD	E2F2 →	+0.827	+3.368	<.001	.004	3	4
UCEC	WDR76 →	+0.734	+2.099	<.001	<.001	3	4
LUAD	OIP5 →	+0.786	+2.150	<.001	.009	3	4
UCEC	MASTL →	+0.381	+2.083	.004	<.001	3	4
UCEC	WRAP53 →	+0.276	+1.408	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,041 associations by consensus.

HELLS by C7 expression — UCEC

Explore this box plot interactively →