C7

Across TCGA patient cohorts, C7 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C7-associated genes across cancer lineages are Chk1, TFRC, and ERCC1. Each is linked with C7 in more than 4 cancer types. Because this analysis shows association rather than direction, both C7-to-partner and partner-to-C7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by C7-low versus C7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C7→partner) and Y-score (partner→C7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk1 →	+0.107	+1.186	.029	.034	3	5
LUAD	TFRC →	+0.608	+1.700	.004	.043	3	4
LUSC	ERCC1 →	+0.208	+1.916	.010	.009	3	3
LUSC	GAPDH →	+0.555	+3.169	.022	.017	3	3
UCEC	PDCD4 →	-0.451	-1.765	<.001	.011	3	3
UCEC	ATM →	-0.540	-2.649	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Chk1 by C7 expression — SKCM

Explore this box plot interactively →