C7

Across TCGA cell cohorts, C7 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,168 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible C7-associated GO terms across cancer lineages are Positive regulation of telomere maintenance via telomere lengthening, Regulation of cell-substrate adhesion, and Negative regulation of RNA catabolic process. Each is linked with C7 in more than 4 cancer types. Because this analysis shows association rather than direction, both C7-to-partner and partner-to-C7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of telomere maintenance via telomere lengthening grouped by C7-low versus C7-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C7→partner) and Y-score (partner→C7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Positive regulation of telomere maintenance via telomere lengthening →	+0.058	+1.006	<.001	.001	3	5
LUNG_NSCLC_LUSC	Regulation of cell-substrate adhesion →	+0.067	+0.103	.004	.007	3	4
CNS	Negative regulation of RNA catabolic process →	+0.042	+1.295	.001	<.001	3	4
CNS	Regulation of syncytium formation by plasma membrane fusion →	+0.067	+1.082	<.001	<.001	3	4
BREAST	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.059	+0.073	<.001	<.001	3	4
BREAST	Striated muscle contraction →	+0.070	+0.105	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,168 associations by consensus.

Positive regulation of telomere maintenance via telomere lengthening by C7 expression — CNS

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