C7

Across TCGA cell cohorts, C7 mutation is significantly associated with the RNA expression of many other genes, with 163 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C7-associated genes across cancer lineages are PARD6A, ASB17, and TMEM233. Each is linked with C7 in more than 1 cancer types. Because this analysis shows association rather than direction, both C7-to-partner and partner-to-C7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PARD6A grouped by C7-low versus C7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C7→partner) and Y-score (partner→C7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PARD6A →	+0.801	+3.169	.002	.009	3	2
LUNG_SCLC	ASB17 →	+0.015	+3.614	<.001	.001	3	2
STOMACH	TMEM233 →	+0.199	+3.632	.007	.009	3	2
BREAST	CACNG3 →	+0.043	+5.169	<.001	.005	3	2
BLOOD_Leukemia	SSTR3 →	+0.957	+3.634	<.001	.002	3	2
URINARY_TRACT	KRT25 →	+0.053	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 163 associations by consensus.

PARD6A by C7 expression — LARGE_INTESTINE

Explore this box plot interactively →