C7

Across TCGA cell cohorts, C7 mutation is significantly associated with the mutation status of many other genes, with 3,323 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C7-associated genes across cancer lineages are SVEP1, CNTN4, and COL5A3. Each is linked with C7 in more than 5 cancer types. Because this analysis shows association rather than direction, both C7-to-partner and partner-to-C7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SVEP1 grouped by C7-low versus C7-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C7→partner) and Y-score (partner→C7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SVEP1 →	+1.888	+2.633	.009	.009	1	6
LUNG_NSCLC_LUAD	CNTN4 →	+5.266	+4.000	<.001	<.001	1	5
PANCREAS	COL5A3 →	+5.115	+5.115	.005	.005	1	4
SKIN	IGSF10 →	+2.350	+1.993	<.001	<.001	1	4
LARGE_INTESTINE	PLIN4 →	+1.959	+2.292	.003	.003	1	4
SKIN	NCOR2 →	+2.350	+1.741	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,323 associations by consensus.

SVEP1 by C7 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →