Across TCGA pan-cancer cohorts, C6orf58 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C6orf58 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher C6orf58 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C6orf58 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where C6orf58 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.439	0.900	.046	4	view →
PDAC	DFS	Median	II,III,IV	0.730	0.296	.026	4	view →
HNSC	OS	Median	All	0.959	1.000	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: C6orf58 tumor-vs-normal RNA expression · all C6orf58 data types