Across TCGA patient cohorts, C6orf58 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C6orf58-associated genes across cancer lineages are Annexin-1, eEF2, and p27_pT198. Each is linked with C6orf58 in more than 1 cancer types. Because this analysis shows association rather than direction, both C6orf58-to-partner and partner-to-C6orf58 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C6orf58→partner) and Y-score (partner→C6orf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Annexin-1 →	+0.709	+3.169	.004	.019	3	2
UCEC	eEF2 →	+0.613	+3.321	.001	.010	3	2
SKCM	p27_pT198 →	-0.152	-3.169	.031	.019	3	1
UCEC	EGFR_pY1068 →	-0.365	-3.000	.005	.036	3	1
UCEC	Heregulin →	-0.182	-2.986	.004	.035	3	1
UCEC	INPP4B →	-0.370	-3.169	.029	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

C6orf58 survival (RNA) · tumor vs normal (RNA) · all C6orf58 data types