Across TCGA patient cohorts, C6orf15 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C6orf15-associated genes across cancer lineages are JNK2, Ku80, and RAD51. Each is linked with C6orf15 in more than 1 cancer types. Because this analysis shows association rather than direction, both C6orf15-to-partner and partner-to-C6orf15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C6orf15→partner) and Y-score (partner→C6orf15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.330	+2.817	.002	.036	3	1
UCEC	Ku80 →	+0.383	+3.183	.003	.010	3	1
UCEC	RAD51 →	+0.228	+3.169	.002	.020	3	1
UCEC	Shc_pY317 →	-0.230	-3.169	.005	.020	3	1
SKCM	p27_pT198 →	+0.203	+2.824	.002	.034	3	1
SKCM	PARP_cleaved →	+0.229	+3.169	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

C6orf15 survival (RNA) · tumor vs normal (RNA) · all C6orf15 data types