C6orf118

Across TCGA patient cohorts, C6orf118 mutation is significantly associated with the RNA expression of many other genes, with 6,158 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C6orf118-associated genes across cancer lineages are ALYREF, IMP4, and RCC1L. Each is linked with C6orf118 in more than 3 cancer types. Because this analysis shows association rather than direction, both C6orf118-to-partner and partner-to-C6orf118 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALYREF grouped by C6orf118-low versus C6orf118-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C6orf118→partner) and Y-score (partner→C6orf118) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALYREF →	+0.654	+3.906	<.001	<.001	3	4
UCEC	IMP4 →	+0.265	+1.660	.002	.002	3	4
UCEC	RCC1L →	+0.252	+1.847	.004	<.001	3	3
UCEC	RRAGC →	+0.479	+3.960	<.001	<.001	3	3
UCEC	FAM151B →	+0.316	+3.776	<.001	<.001	3	3
UCEC	FGD5 →	-0.574	-2.432	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,158 associations by consensus.

ALYREF by C6orf118 expression — UCEC

Explore this box plot interactively →