C5orf66-AS2

Across TCGA pan-cancer cohorts, C5orf66-AS2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated C5orf66-AS2 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher C5orf66-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C5orf66-AS2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

ACC, HNSC, and KICH are the cancer types where C5orf66-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	II,III,IV	0.287	0.591	.009	34	view →
HNSC	OS	Tertile	All	0.831	0.716	.004	34	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	27	view →
SKCM	OS	Tertile	All	0.726	0.879	.005	27	view →
UCS	DFS	Tertile	II,III,IV	0.699	0.339	.018	24	view →
KIRP	DFS	Tertile	All	0.698	0.882	.001	15	view →
BLCA	OS	Tertile	III,IV	0.813	0.518	.020	12	view →
READ	DFS	Tertile	IV	0.095	0.697	.014	9	view →
THYM	DFS	Tertile	II,III,IV	0.262	0.769	.032	6	view →
LUAD	OS	Tertile	All	0.169	0.426	.042	6	view →
BRCA	DFS	Tertile	All	0.923	0.891	.025	4	view →
LIHC	OS	Tertile	All	0.661	0.796	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

C5orf66-AS2–ACC (DFS)

Open the ACC breakdown →