Across TCGA patient cohorts, C5orf52 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5orf52-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and Shc_pY317. Each is linked with C5orf52 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf52-to-partner and partner-to-C5orf52 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf52→partner) and Y-score (partner→C5orf52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.208	-2.999	.014	.035	3	1
UCEC	Ku80 →	+0.295	+2.335	.012	.020	3	1
UCEC	Shc_pY317 →	-0.234	-3.459	.002	.005	3	1
UCEC	ASNS →	+0.614	+2.321	<.001	.035	2	2
UCEC	BRD4 →	+0.355	+2.329	.008	.020	3	1
UCEC	Notch1 →	+0.174	+2.321	.013	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

C5orf52 survival (RNA) · tumor vs normal (RNA) · all C5orf52 data types