Across TCGA patient cohorts, C5orf51 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5orf51-associated genes across cancer lineages are MEK1, Notch1, and C-Raf. Each is linked with C5orf51 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf51-to-partner and partner-to-C5orf51 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf51→partner) and Y-score (partner→C5orf51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.466	+3.459	.011	.005	3	2
UCEC	Notch1 →	+0.174	+2.321	.014	.035	3	2
UCEC	C-Raf →	+0.156	+2.321	.030	.035	3	2
UCEC	JNK2 →	+0.331	+2.817	<.001	.036	3	1
UCEC	Ku80 →	+0.397	+3.472	<.001	.002	3	1
UCEC	PKC-b-II_pS660 →	-0.350	-2.321	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

C5orf51 survival (RNA) · tumor vs normal (RNA) · all C5orf51 data types