Across TCGA pan-cancer cohorts, C5orf47 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of C5orf47’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where C5orf47 RNA is repressed in tumor relative to normal tissue. In most cancer types C5orf47 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.
KIRP, KIRC, and THCA are the cancer types where C5orf47 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C5orf47 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.