C5orf34

Across TCGA pan-cancer cohorts, C5orf34 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C5orf34 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher C5orf34 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated C5orf34 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, CESC, and HNSC are the cancer types where C5orf34 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.304	.006	34	view →
CESC	OS	Median	II,III,IV	0.264	0.765	.011	18	view →
HNSC	OS	Median	IV	0.010	0.733	<.001	15	view →
SKCM	DFS	Median	III,IV	0.040	0.597	<.001	9	view →
LIHC	OS	Median	All	0.258	0.773	.023	6	view →
LUAD	DFS	Median	All	0.213	0.676	.012	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

C5orf34–UCEC (DFS)

Open the UCEC breakdown →