C5orf34

Across TCGA patient cohorts, C5orf34 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5orf34-associated genes across cancer lineages are EGFR, INPP4B, and Notch1. Each is linked with C5orf34 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf34-to-partner and partner-to-C5orf34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by C5orf34-low versus C5orf34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf34→partner) and Y-score (partner→C5orf34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.182	-3.321	.005	.010	3	1
UCEC	INPP4B →	-0.290	-3.169	.030	.018	3	1
UCEC	Notch1 →	+0.168	+1.884	.003	.030	3	1
UCEC	p27_pT198 →	+0.100	+2.321	.023	.006	3	1
UCEC	p62 Lck ligand →	+0.373	+3.169	.005	.018	3	1
UCEC	STAT3_pY705 →	-0.380	-2.321	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR by C5orf34 expression — UCEC

Explore this box plot interactively →