C5orf34

Across TCGA cell cohorts, C5orf34 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,073 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C5orf34-associated GO terms across cancer lineages are Negative regulation of metaphase/anaphase transition of cell cycle, Negative regulation of chromosome separation, and Centrosome cycle. Each is linked with C5orf34 in more than 19 cancer types. Because this analysis shows association rather than direction, both C5orf34-to-partner and partner-to-C5orf34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of metaphase/anaphase transition of cell cycle grouped by C5orf34-low versus C5orf34-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf34→partner) and Y-score (partner→C5orf34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.141	+0.919	<.001	.006	3	20
LIVER	Negative regulation of chromosome separation →	+0.141	+0.919	<.001	.006	3	20
PANCREAS	Centrosome cycle →	+0.097	+0.962	<.001	<.001	3	20
BLOOD_Myeloma	Nuclear chromosome segregation →	+0.116	+1.193	<.001	<.001	3	19
BONE	Protein localization to condensed chromosome →	+0.177	+0.872	.009	.006	3	19
BLOOD_Myeloma	Positive regulation of chromosome condensation →	+0.266	+1.247	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,073 associations by consensus.

Negative regulation of metaphase/anaphase transition of cell cycle by C5orf34 expression — LIVER

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