C5orf24

Across TCGA patient cohorts, C5orf24 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5orf24-associated genes across cancer lineages are FASN, JNK_pT183_Y185, and C-Raf. Each is linked with C5orf24 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf24-to-partner and partner-to-C5orf24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by C5orf24-low versus C5orf24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf24→partner) and Y-score (partner→C5orf24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.396	+1.584	.005	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.136	-2.115	.025	.017	3	2
UCEC	C-Raf →	+0.124	+2.115	.016	.017	3	2
UCEC	14-3-3_beta →	-0.077	-1.847	.032	.049	3	1
UCEC	EGFR_pY1068 →	-0.224	-1.584	.013	.019	3	1
UCEC	eIF4E →	+0.157	+1.925	.038	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

FASN by C5orf24 expression — UCEC

Explore this box plot interactively →