C5orf22

Across TCGA patient cohorts, C5orf22 mutation is significantly associated with the RNA expression of many other genes, with 889 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5orf22-associated genes across cancer lineages are RNA5SP412, LINC02462, and LINC02745. Each is linked with C5orf22 in more than 2 cancer types. Because this analysis shows association rather than direction, both C5orf22-to-partner and partner-to-C5orf22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by C5orf22-low versus C5orf22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf22→partner) and Y-score (partner→C5orf22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.552	+2.092	<.001	.007	3	3
LUAD	LINC02462 →	+0.444	+5.554	<.001	.004	3	2
LUAD	LINC02745 →	+0.148	+6.912	<.001	<.001	3	2
PRAD	IGHD6-19 →	+1.267	+5.420	<.001	.005	3	2
LIHC	SNORA10B →	+0.266	+4.878	<.001	.005	3	2
LIHC	MIR3684 →	+0.442	+5.902	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 889 associations by consensus.

RNA5SP412 by C5orf22 expression — UCEC

Explore this box plot interactively →