C5orf22

Across TCGA patient cohorts, C5orf22 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5orf22-associated genes across cancer lineages are TIGAR, Ku80, and MEK1. Each is linked with C5orf22 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf22-to-partner and partner-to-C5orf22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by C5orf22-low versus C5orf22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf22→partner) and Y-score (partner→C5orf22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.188	+2.611	.008	.006	3	2
UCEC	Ku80 →	+0.217	+1.887	.048	.031	3	1
UCEC	MEK1 →	+0.381	+3.169	.025	.019	3	1
UCEC	p62 Lck ligand →	+0.419	+3.331	.005	.005	3	1
UCEC	Chk2 →	-0.280	-2.584	.010	.011	3	1
UCEC	Annexin-1 →	+0.733	+2.584	.002	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TIGAR by C5orf22 expression — UCEC

Explore this box plot interactively →