C5orf22

Across TCGA cell cohorts, C5orf22 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,854 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible C5orf22-associated GO terms across cancer lineages are Protein localization to nuclear inner membrane, Establishment of mitotic sister chromatid cohesion, and Cellular response to rapamycin. Each is linked with C5orf22 in more than 17 cancer types. Because this analysis shows association rather than direction, both C5orf22-to-partner and partner-to-C5orf22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to nuclear inner membrane grouped by C5orf22-low versus C5orf22-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf22→partner) and Y-score (partner→C5orf22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Protein localization to nuclear inner membrane →	+0.190	+1.283	<.001	<.001	3	18
OESOPHAGUS	Establishment of mitotic sister chromatid cohesion →	+0.134	+0.913	.001	.003	3	15
LUNG_NSCLC_LUSC	Cellular response to rapamycin →	+0.166	+1.162	<.001	.001	2	13
LUNG_NSCLC_LUSC	Response to rapamycin →	+0.179	+1.181	<.001	<.001	2	13
OVARY	Positive regulation of cytoplasmic translation →	+0.171	+1.050	<.001	<.001	3	11
OVARY	Nuclear envelope organization →	+0.074	+0.801	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,854 associations by consensus.

Protein localization to nuclear inner membrane by C5orf22 expression — URINARY_TRACT

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