C5orf22

Across TCGA cell cohorts, C5orf22 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C5orf22-associated genes across cancer lineages are OR13G1, NPHS2, and MSGN1. Each is linked with C5orf22 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf22-to-partner and partner-to-C5orf22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13G1 grouped by C5orf22-low versus C5orf22-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf22→partner) and Y-score (partner→C5orf22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR13G1 →	+0.055	+5.321	<.001	.005	3	1
LARGE_INTESTINE	NPHS2 →	+0.073	+4.029	.009	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	LCE1C →	+0.062	+3.684	.004	.006	3	1
LARGE_INTESTINE	SPRR2F →	+0.467	+3.707	.007	.009	3	1
OVARY	SPACA1 →	+0.023	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR13G1 by C5orf22 expression — CNS

Explore this box plot interactively →