C5orf22

Across TCGA cell cohorts, C5orf22 mutation is significantly associated with the mutation status of many other genes, with 1,432 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C5orf22-associated genes across cancer lineages are ZNF433, ZC3H11A, and TET1. Each is linked with C5orf22 in more than 2 cancer types. Because this analysis shows association rather than direction, both C5orf22-to-partner and partner-to-C5orf22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF433 grouped by C5orf22-low versus C5orf22-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf22→partner) and Y-score (partner→C5orf22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF433 →	+4.415	+4.977	.007	.007	1	3
LARGE_INTESTINE	ZC3H11A →	+2.459	+3.321	.005	.005	1	3
LARGE_INTESTINE	TET1 →	+1.974	+3.801	.004	.004	1	3
OVARY	ZC3H3 →	+4.415	+4.977	.007	.007	1	2
OVARY	ITPK1 →	+5.415	+5.415	.004	.004	1	2
OVARY	C14orf93 →	+4.415	+4.977	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,432 associations by consensus.

ZNF433 by C5orf22 expression — OVARY

Explore this box plot interactively →