C5orf17

Across TCGA pan-cancer cohorts, C5orf17 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated C5orf17 data layer compared with 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher C5orf17 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C5orf17 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUSC, LUAD, and HNSC are the cancer types where C5orf17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Quartile	II,III,IV	0.345	0.818	<.001	67	view →
LUAD	DFS	Median	III,IV	0.691	0.242	<.001	52	view →
HNSC	DFS	Quartile	All	0.385	0.248	.004	48	view →
UVM	OS	Median	All	0.404	0.797	.015	24	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	19	view →
KIRC	OS	Tertile	All	0.899	0.838	.015	15	view →
CESC	DFS	Tertile	All	0.747	0.847	.025	10	view →
READ	DFS	Median	IV	0.431	0.787	.026	9	view →
BRCA	DFS	Quartile	III,IV	0.751	0.444	.010	8	view →
ESCA	DFS	Tertile	All	0.455	0.870	.018	7	view →
LIHC	DFS	Tertile	II,III,IV	0.547	0.343	.029	7	view →
UCS	DFS	Quartile	II,III,IV	0.781	0.315	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

C5orf17–LUSC (DFS)

Open the LUSC breakdown →