C5orf15

Across TCGA pan-cancer cohorts, C5orf15 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C5orf15 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C5orf15 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C5orf15 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where C5orf15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.335	0.923	<.001	52	view →
HNSC	DFS	Median	II,III,IV	0.860	0.673	.001	46	view →
PDAC	OS	Median	All	0.691	0.880	.010	12	view →
LUAD	DFS	Quartile	II,III,IV	0.421	0.789	.022	5	view →
LSCC	DFS	Median	III,IV	0.467	0.824	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C5orf15–CCRCC (OS)

Open the CCRCC breakdown →