C5orf15

Across TCGA pan-cancer cohorts, C5orf15 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of C5orf15’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where C5orf15 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C5orf15 is over-expressed in tumor.

PDAC, CCRCC, and LUAD are the cancer types where C5orf15 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C5orf15 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	III,IV	+0.960	<.001	10	view →
CCRCC	Male	III,IV	+0.668	<.001	10	view →
LUAD	Male	II,III,IV	+0.669	<.001	8	view →
LSCC	All	III,IV	+0.549	<.001	8	view →
HNSC	All	II,III,IV	+0.425	<.001	6	view →
COAD	Female	All	+0.365	.030	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

C5orf15–PDAC

Open the PDAC breakdown →