C5orf15

Across TCGA patient cohorts, C5orf15 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5orf15-associated genes across cancer lineages are MEK1, Notch1, and VHL. Each is linked with C5orf15 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf15-to-partner and partner-to-C5orf15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by C5orf15-low versus C5orf15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf15→partner) and Y-score (partner→C5orf15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.434	+3.169	.023	.019	3	1
UCEC	Notch1 →	+0.217	+3.321	.003	.010	3	1
UCEC	VHL →	-1.113	-3.321	.001	.010	3	1
UCEC	Cyclin-B1 →	+0.820	+3.321	.005	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MEK1 by C5orf15 expression — UCEC

Explore this box plot interactively →