Across TCGA pan-cancer cohorts, C5AR1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated C5AR1 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher C5AR1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated C5AR1 expression acts as an unfavorable survival marker.

BLCA and SCLC are the cancer types where C5AR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.158	0.598	.007	15	view →
SCLC	DFS	Median	All	0.192	0.793	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: C5AR1 tumor-vs-normal RNA expression · all C5AR1 data types