Across TCGA pan-cancer cohorts, C5AR1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C5AR1 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher C5AR1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C5AR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where C5AR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.661	0.905	.001	37	view →
HNSC	OS	Tertile	IV	0.895	0.457	<.001	29	view →
CCRCC	DFS	Tertile	All	0.105	0.904	.008	24	view →
UCEC	DFS	Median	All	0.816	1.000	.028	6	view →
GBM	OS	Tertile	All	0.270	0.437	.034	2	view →
LUAD	OS	Tertile	II,III,IV	0.904	0.423	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: C5AR1 tumor-vs-normal RNA expression · all C5AR1 data types