Across TCGA patient cohorts, C5AR1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible C5AR1-associated genes across cancer lineages are Caveolin-1, TIGAR, and YB-1. Each is linked with C5AR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5AR1-to-partner and partner-to-C5AR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5AR1→partner) and Y-score (partner→C5AR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Caveolin-1 →	+0.931	+3.169	.005	.019	3	2
SKCM	TIGAR →	-0.195	-3.169	.005	.019	3	1
SKCM	YB-1 →	+0.334	+2.820	.002	.035	2	1
SKCM	JNK_pT183_Y185 →	+0.154	+3.169	.037	.019	1	1
UCEC	Ku80 →	+0.324	+2.820	.025	.036	1	1
UCEC	14-3-3_zeta →	+0.249	+2.833	.049	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

C5AR1 survival (RNA) · tumor vs normal (RNA) · all C5AR1 data types