Across TCGA cell cohorts, C5AR1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C5AR1-associated genes across cancer lineages are ARR3, CILP, and MDGA2. Each is linked with C5AR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5AR1-to-partner and partner-to-C5AR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5AR1→partner) and Y-score (partner→C5AR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARR3 →	+0.232	+3.745	<.001	.002	3	1
LARGE_INTESTINE	CILP →	+0.170	+3.443	<.001	.009	3	1
LARGE_INTESTINE	MDGA2 →	+0.157	+3.439	<.001	<.001	3	1
LARGE_INTESTINE	BEND2 →	+0.016	+3.240	<.001	.004	3	1
LARGE_INTESTINE	C9orf153 →	+0.158	+3.497	<.001	.004	3	1
LARGE_INTESTINE	MOG →	+0.111	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

C5AR1 survival (RNA) · tumor vs normal (RNA) · all C5AR1 data types