C5

Across TCGA patient cohorts, C5 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,715 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible C5-associated proteins across cancer lineages are SETMAR, FBXO4, and TRIM29_S489. Each is linked with C5 in more than 4 cancer types. Because this analysis shows association rather than direction, both C5-to-partner and partner-to-C5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C5 versus SETMAR in HNSC, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C5→partner) and Y-score (partner→C5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SETMAR →	+0.372	+0.584	<.001	<.001	3	5
HNSC	FBXO4 →	+0.446	+0.837	<.001	<.001	3	5
BRCA	TRIM29_S489 →	-0.995	-0.649	.002	<.001	3	5
HNSC	NFIC →	+0.397	+0.843	<.001	<.001	3	5
BRCA	PFKP →	-0.714	-0.785	<.001	<.001	3	4
PDAC	PKM_S37 →	-0.682	-0.453	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,715 associations by consensus.

C5 vs SETMAR — HNSC

Explore this scatter interactively →