C5

Across TCGA patient cohorts, C5 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5-associated genes across cancer lineages are Notch1, Bak, and 14-3-3_beta. Each is linked with C5 in more than 3 cancer types. Because this analysis shows association rather than direction, both C5-to-partner and partner-to-C5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by C5-low versus C5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5→partner) and Y-score (partner→C5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Notch1 →	+0.211	+1.887	.006	.029	3	4
COAD	Bak →	+0.118	+3.012	.046	.018	3	3
UCEC	14-3-3_beta →	-0.075	-1.710	.010	.005	3	2
UCEC	FoxM1 →	+0.201	+1.432	.008	.005	3	2
UCEC	MEK1 →	+0.347	+2.906	.001	.001	3	2
UCEC	p27_pT198 →	+0.069	+1.502	.028	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Notch1 by C5 expression — SKCM

Explore this box plot interactively →