C5

Across TCGA cell cohorts, C5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,115 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible C5-associated GO terms across cancer lineages are Negative regulation of macrophage chemotaxis, Negative regulation of macrophage migration, and DNA biosynthetic process. Each is linked with C5 in more than 17 cancer types. Because this analysis shows association rather than direction, both C5-to-partner and partner-to-C5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of macrophage chemotaxis grouped by C5-low versus C5-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C5→partner) and Y-score (partner→C5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of macrophage chemotaxis →	-0.188	-1.944	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Negative regulation of macrophage migration →	-0.301	-1.425	.002	<.001	3	13
BREAST	DNA biosynthetic process →	+0.055	+1.087	.005	.002	3	11
LARGE_INTESTINE	DNA damage tolerance →	+0.062	+1.038	<.001	<.001	3	10
SOFT_TISSUE	Regulation of sister chromatid cohesion →	+0.121	+0.833	<.001	.004	3	10
BLOOD_Leukemia	Protein polymerization →	+0.063	+0.841	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,115 associations by consensus.

Negative regulation of macrophage chemotaxis by C5 expression — STOMACH

Explore this box plot interactively →