C4orf54

Across TCGA patient cohorts, C4orf54 protein abundance is significantly associated with the RNA expression of many other genes, with 1,926 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible C4orf54-associated genes across cancer lineages are NUBP1, HAR1A, and PLAUR. Each is linked with C4orf54 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf54-to-partner and partner-to-C4orf54 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C4orf54 versus NUBP1 in LUAD, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf54→partner) and Y-score (partner→C4orf54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NUBP1 →	-0.403	-0.798	.001	.002	3	2
LUAD	HAR1A →	-0.517	-0.620	.008	.009	3	2
LUAD	PLAUR →	+1.299	+0.649	.002	.002	3	2
HNSC	LBP →	+1.265	+0.897	.002	.001	3	2
HNSC	ANKRD1 →	+2.744	+0.795	<.001	<.001	3	2
LSCC	CTSC →	+0.518	+0.710	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,926 associations by consensus.

C4orf54 vs NUBP1 — LUAD

Explore this scatter interactively →