C4orf54

Across TCGA patient cohorts, C4orf54 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4orf54-associated genes across cancer lineages are Heregulin, Ku80, and MEK1. Each is linked with C4orf54 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf54-to-partner and partner-to-C4orf54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by C4orf54-low versus C4orf54-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf54→partner) and Y-score (partner→C4orf54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.252	-3.169	<.001	.020	3	1
UCEC	Ku80 →	+0.450	+3.183	<.001	.009	3	1
UCEC	MEK1 →	+0.583	+3.169	.003	.019	3	1
UCEC	N-Ras →	-0.260	-2.980	<.001	.036	3	1
UCEC	AMPK_pT172 →	+0.450	+3.183	.046	.010	3	1
UCEC	Tuberin →	+0.613	+3.009	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Heregulin by C4orf54 expression — UCEC

Explore this box plot interactively →