C4orf48

Across TCGA patient cohorts, C4orf48 protein abundance is significantly associated with the RNA expression of many other genes, with 518 significant associations in total. GBM shows the largest number of these associations.

The most reproducible C4orf48-associated genes across cancer lineages are GRAP2, IL2RB, and PROKR2. Each is linked with C4orf48 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf48-to-partner and partner-to-C4orf48 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C4orf48 versus GRAP2 in GBM, with a Pearson correlation of -0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf48→partner) and Y-score (partner→C4orf48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GRAP2 →	-0.675	-0.817	.005	.005	3	1
GBM	IL2RB →	-1.062	-0.766	.005	.005	3	1
GBM	PROKR2 →	+0.365	+1.065	.002	.001	3	1
GBM	TLR8 →	-1.552	-0.735	<.001	.004	3	1
GBM	ARHGEF7 →	+0.637	+0.733	.005	.006	3	1
GBM	SGCG →	+0.694	+0.571	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 518 associations by consensus.

C4orf48 vs GRAP2 — GBM

Explore this scatter interactively →