C4orf48

Across TCGA cell cohorts, C4orf48 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,294 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible C4orf48-associated GO terms across cancer lineages are Transcription pausing by RNA polymerase II, Clathrin coat disassembly, and ATP metabolic process. Each is linked with C4orf48 in more than 12 cancer types. Because this analysis shows association rather than direction, both C4orf48-to-partner and partner-to-C4orf48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription pausing by RNA polymerase II grouped by C4orf48-low versus C4orf48-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf48→partner) and Y-score (partner→C4orf48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Transcription pausing by RNA polymerase II →	+0.213	+2.580	<.001	<.001	3	12
BREAST	Clathrin coat disassembly →	+0.144	+2.004	<.001	<.001	2	13
OESOPHAGUS	ATP metabolic process →	+0.109	+1.921	.002	<.001	3	11
OESOPHAGUS	Nucleoside triphosphate biosynthetic process →	+0.096	+1.336	<.001	<.001	3	11
OESOPHAGUS	Ribonucleoside triphosphate biosynthetic process →	+0.102	+1.336	<.001	<.001	3	11
BONE	ATP biosynthetic process →	+0.081	+1.376	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,294 associations by consensus.

Transcription pausing by RNA polymerase II by C4orf48 expression — BONE

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