Across TCGA patient cohorts, C4orf46 protein abundance is significantly associated with the RNA expression of many other genes, with 931 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible C4orf46-associated genes across cancer lineages are CDKN2D, MMP13, and RNF217. Each is linked with C4orf46 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf46-to-partner and partner-to-C4orf46 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf46→partner) and Y-score (partner→C4orf46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDKN2D →	+1.277	+0.736	.003	.004	3	2
OV	MMP13 →	+2.657	+0.703	.009	.008	3	2
BRCA	RNF217 →	+1.012	+0.415	.001	<.001	3	2
LUAD	CKAP2L →	+1.214	+0.491	.007	<.001	3	2
LUAD	TRIM47 →	+1.045	+0.590	<.001	<.001	3	2
BRCA	ZGRF1 →	+0.665	+0.481	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 931 associations by consensus.

Exploration

C4orf46 survival (RNA) · tumor vs normal (RNA) · all C4orf46 data types