Across TCGA patient cohorts, C4orf46 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4orf46-associated genes across cancer lineages are EGFR_pY1068, GSK3-a-b, and Rad50. Each is linked with C4orf46 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf46-to-partner and partner-to-C4orf46 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf46→partner) and Y-score (partner→C4orf46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.333	-3.000	.021	.037	3	1
UCEC	GSK3-a-b →	+0.164	+3.000	.036	.037	3	1
UCEC	Rad50 →	-0.279	-3.000	.047	.037	3	1
UCEC	ERK2 →	+0.325	+3.000	.003	.037	2	1
UCEC	Heregulin →	-0.211	-3.000	.003	.037	1	1
UCEC	PDCD4 →	-0.609	-3.000	.025	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

C4orf46 survival (RNA) · tumor vs normal (RNA) · all C4orf46 data types