C4orf3

Across TCGA pan-cancer cohorts, C4orf3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C4orf3 data layer compared with 20 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C4orf3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C4orf3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where C4orf3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.775	0.497	<.001	104	view →
CCRCC	OS	Quartile	All	0.696	0.955	.003	30	view →
PDAC	DFS	Tertile	III,IV	0.408	0.998	.004	20	view →
LSCC	DFS	Quartile	All	1.000	0.913	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C4orf3–HNSC (DFS)

Open the HNSC breakdown →