C4orf3

Across TCGA patient cohorts, C4orf3 protein abundance is significantly associated with the RNA expression of many other genes, with 8,580 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4orf3-associated genes across cancer lineages are DEGS1, NVL, and DOLPP1. Each is linked with C4orf3 in more than 4 cancer types. Because this analysis shows association rather than direction, both C4orf3-to-partner and partner-to-C4orf3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C4orf3 versus DEGS1 in HNSC, with a Pearson correlation of 0.24.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf3→partner) and Y-score (partner→C4orf3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DEGS1 →	+0.905	+0.523	.001	<.001	2	5
BRCA	NVL →	+0.513	+0.784	.001	.005	3	3
LSCC	DOLPP1 →	+0.512	+0.367	<.001	<.001	3	3
BRCA	FRMD3 →	-0.927	-0.735	<.001	.003	3	3
UCEC	CCSAP →	+0.676	+0.734	<.001	.001	3	3
LSCC	PLCL2 →	-0.594	-0.415	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,580 associations by consensus.

C4orf3 vs DEGS1 — HNSC

Explore this scatter interactively →