C4orf3

Across TCGA patient cohorts, C4orf3 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4orf3-associated genes across cancer lineages are MBD3L3, RN7SKP86, and RNU6-169P. Each is linked with C4orf3 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf3-to-partner and partner-to-C4orf3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L3 grouped by C4orf3-low versus C4orf3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf3→partner) and Y-score (partner→C4orf3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MBD3L3 →	+0.129	+7.741	<.001	.009	3	2
UCEC	RN7SKP86 →	+0.240	+2.755	.006	.009	3	2
HNSC	RNU6-169P →	+0.273	+7.954	<.001	.008	3	1
UCEC	MIR7974 →	+0.449	+2.715	.008	.006	3	1
UCEC	MIR6085 →	+0.484	+3.221	.004	.001	3	1
UCEC	MIR6839 →	+0.400	+3.299	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

MBD3L3 by C4orf3 expression — COAD

Explore this box plot interactively →