C4BPB

Across TCGA pan-cancer cohorts, C4BPB mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated C4BPB data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher C4BPB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C4BPB expression acts as an unfavorable survival marker, although some lineages such as OV and HNSC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where C4BPB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.611	0.972	.001	16	view →
LSCC	OS	Median	All	0.937	1.000	.011	15	view →
UCEC	OS	Median	All	0.907	1.000	.010	12	view →
LUAD	OS	Median	II,III,IV	0.280	0.800	.003	10	view →
CCRCC	DFS	Median	All	0.709	1.000	.010	9	view →
COAD	DFS	Median	All	0.888	1.000	.023	6	view →
GBM	DFS	Median	All	0.284	0.456	.020	6	view →
OV	DFS	Median	All	1.000	0.869	.039	4	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.928	.033	4	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

C4BPB–PDAC (OS)

Open the PDAC breakdown →