C4BPAP2

Across TCGA pan-cancer cohorts, C4BPAP2 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated C4BPAP2 data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher C4BPAP2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated C4BPAP2 expression acts as an unfavorable survival marker, although some lineages such as ESCA and SARC show a favorable association.

ESCA, ACC, and SARC are the cancer types where C4BPAP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.417	0.198	<.001	44	view →
ACC	DFS	Tertile	All	0.257	0.639	.013	28	view →
SARC	DFS	Quartile	All	0.677	0.468	.001	22	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →
COAD	DFS	Tertile	IV	0.312	0.522	.016	18	view →
MESO	DFS	Tertile	All	0.251	0.528	.035	15	view →
KIRC	DFS	Quartile	IV	0.326	0.681	.002	14	view →
LIHC	OS	Tertile	All	0.790	0.440	.016	12	view →
GBM	DFS	Tertile	All	0.080	0.292	.008	9	view →
READ	OS	Tertile	III,IV	0.638	0.883	.046	9	view →
BRCA	OS	Quartile	All	0.981	0.956	.022	8	view →
HNSC	DFS	Quartile	All	0.798	0.559	.010	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

C4BPAP2–ESCA (DFS)

Open the ESCA breakdown →