Across TCGA pan-cancer cohorts, C4B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C4B data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher C4B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C4B expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

CESC, LUSC, and ACC are the cancer types where C4B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.068	0.830	<.001	30	view →
LUSC	DFS	Median	II,III,IV	1.000	0.368	.019	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: C4B tumor-vs-normal RNA expression · all C4B data types