Across TCGA pan-cancer cohorts, C4B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C4B data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher C4B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C4B expression acts as an unfavorable survival marker.

LSCC, UCEC, and CCRCC are the cancer types where C4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	III,IV	0.335	0.839	.014	11	view →
UCEC	OS	Quartile	All	0.868	1.000	.017	6	view →
CCRCC	DFS	Quartile	III,IV	0.233	0.887	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: C4B tumor-vs-normal RNA expression · all C4B data types