Across TCGA patient cohorts, C4B RNA expression is significantly associated with the protein abundance of many other proteins, with 19,654 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C4B-associated proteins across cancer lineages are BDH2, KPNA2, and LUM. Each is linked with C4B in more than 5 cancer types. Because this analysis shows association rather than direction, both C4B-to-partner and partner-to-C4B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C4B→partner) and Y-score (partner→C4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BDH2 →	+0.409	+0.980	.002	.002	3	6
BRCA	KPNA2 →	-0.678	-1.918	<.001	<.001	3	5
BRCA	LUM →	+1.037	+1.987	<.001	<.001	3	5
UCEC	ANXA6 →	+0.474	+0.833	<.001	.002	3	5
GBM	NAA20 →	-0.290	-0.846	<.001	<.001	3	5
BRCA	PRRC2C →	-0.262	-1.838	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,654 associations by consensus.

Exploration

C4B survival (RNA) · tumor vs normal (RNA) · all C4B data types