Across TCGA patient cohorts, C4B protein abundance is significantly associated with the RNA expression of many other genes, with 10,866 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible C4B-associated genes across cancer lineages are OLFML2B, AOC3, and MEDAG. Each is linked with C4B in more than 6 cancer types. Because this analysis shows association rather than direction, both C4B-to-partner and partner-to-C4B results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4B→partner) and Y-score (partner→C4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	OLFML2B →	+1.265	+0.746	<.001	<.001	3	7
LSCC	AOC3 →	+1.010	+0.557	<.001	<.001	3	7
COAD	MEDAG →	+0.844	+0.438	<.001	<.001	3	6
BRCA	CD93 →	+0.794	+0.539	<.001	<.001	3	6
CCRCC	VEGFC →	+0.908	+0.681	<.001	<.001	3	6
BRCA	ADGRL4 →	+0.692	+0.530	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,866 associations by consensus.

Exploration

C4B survival (RNA) · tumor vs normal (RNA) · all C4B data types